M. Ross Bullock, M.D., Ph.D.

Preclinical Mechanistic and Neuroprotection Research in Traumatic Brain Injury and Clinical trials, and Neuromonitoring Techniques in the Injured Brain

Many mechanisms of injury, and strategies for neuroprotection and repair, are common to both Severe Traumatic Brain injury, and Spinal cord injury. Cell replacement therapy, either mediated by neurotrophin augmentation of endogenous Progenitor cells, or transplantation strategies, has become an important lab focus, since the award of an RO1 entitled “Modulation of Hippocampal Neurogenesis and Cognitive recovery after neurotrauma”.This offers the prospect of enhancing recovery, in patients with residual severe neurological deficit, after TBI. New therapies, such as perfluorocarbons offer the prospect of ameliorting the neuronal death that occurs, in TBI, and Strategies for their use will be explored in animal models, and human trials.